论文部分内容阅读
目的:探讨并评价三维磁共振波谱成像(3D MRSI)在前列腺内皮瘤(PIN)中的成像特点。方法:对38例前列腺特异性抗原(PSA)升高疑为前列腺癌的患者行MRI+3D MRSI检查,再经直肠彩色多普勒超声引导定位下对可疑位点穿刺行病理检查,另外收集20例同时期良性前列腺增生患者的MRI及MRS资料,回顾性分析前列腺病变部位、常规MRI特征、MRS检查结果,计算(胆碱+肌酸)/枸橼酸盐(CC/C)。采用重复测量方差分析比较良性前列腺增生(BPH)组、前列腺癌(PCa)组、低级别PIN(LG PIN)及高级别PIN(HG PIN)的CC/C差异。结果:20例BPH组患者CC/C值为0.62±0.21;7例LG PIN的CC/C为0.76±0.22,两组患者无明显统计学差异;11例HG PIN患者的T2WI患者外周带有明显或可疑低信号区,3D MRSI示枸橼酸盐峰值稍下降,胆碱峰变化不明显,CC/C值为1.72±0.49;20例PCa患者的T2WI的外周带明显低信号区,3DMRSI示枸橼酸盐峰值几乎均下降明显,胆碱峰升高,CC/C值3.49±1.64,LG PIN组与HG PIN及PCa组差异有统计学意义,与BPH组差异无统计学意义,HG PIN的CC/C值与其它各组的值差异有统计学意义(F=95,P<0.05);结论:LG PIN的3D MRSI表现类似于良性前列腺增生,而HG PIN的3D MRSI改变则更接近于前列腺癌。
Objective: To investigate and evaluate the imaging features of three-dimensional magnetic resonance spectroscopy (3D MRSI) in prostatic intraepithelial neoplasia (PIN). Methods: MRI + 3D MRSI was performed on 38 patients with suspected prostate cancer who had elevated prostate-specific antigen (PSA). Pathologic examination of the suspicious sites was performed under the guidance of rectal color Doppler ultrasound. In addition, 20 Cases of benign prostatic hyperplasia patients with MRI and MRS data, retrospective analysis of prostate lesions, MRI features, MRS results, calculated (choline + creatine) / citrate (CC / C). Repeated measures of analysis of variance were used to compare CC / C differences between BPH group, PCa group, LG PIN and HG PIN. Results: The CC / C value of 20 BPH patients was 0.62 ± 0.21; the CC / C of 7 LG PINs was 0.76 ± 0.22, there was no significant difference between the two groups; in 11 HG PIN patients, Or suspicious low signal region. 3D MRSI showed a slight decrease of citrate peak and a slight change of choline peak with a CC / C value of 1.72 ± 0.49. The peripheral region of T2WI in 20 PCa patients showed a significantly lower signal region, Citrate peak almost all decreased significantly, choline peak increased, CC / C value 3.49 ± 1.64, LG PIN group and HG PIN and PCa group was statistically significant difference with the BPH group was no significant difference, HG PIN Conclusion: The 3D MRSI of LG PIN is similar to that of benign prostatic hyperplasia, while the 3D MRSI of HG PIN is more similar to that of other groups (F = 95, P <0.05) Prostate cancer.