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Ki-67存在于增殖细胞中,参与驱动细胞周期的调控网络,是目前研究较热门的细胞增殖的标记之一。Ki-67在多种肿瘤中均有显著性的改变,不仅在肿瘤的分级、增生程度及预后的预测中有一定意义,而且能可靠地反映正常和病变的增殖活性,可辅助用于鉴别疾病的良、恶性及选择及选择恶性肿瘤早期诊断治疗方法和评估疗效。尤其在妇科肿瘤方面有很多研究报道,本文将Ki-67在妇科常见肿瘤中地研究进展作一综述,希望给妇科临床医师以帮助。
Ki-67 is present in proliferating cells and is involved in the regulatory networks that drive the cell cycle. It is one of the most popular markers for cell proliferation. Ki-67 in a variety of tumors have a significant change, not only in the tumor grade, degree of proliferation and prognosis of a certain significance, but also can reliably reflect the normal and pathological proliferative activity can be used to identify the disease Of the benign and malignant and choose and choose the early diagnosis and treatment of malignant tumors and evaluate the efficacy. Especially in gynecologic oncology there are many reports, this article will review the progress of Ki-67 in gynecological common tumors, hoping to help gynecological clinicians.