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组胺通过H_1和H_2受体介导对心脏功能产生不同的影响,组胺H_2受体阻滞剂是否对心功能存在不利作用,本文评价了三种H_2受体阻滞剂——西咪替丁、雷尼替丁和法莫替丁对血液动力学参数的影响。方法 10例志愿健康受试者,采用随机双盲对照研究。每人分别接受西咪替丁800mg、雷尼替丁300mg、法莫替丁40mg或安慰剂,每日1次,治疗7天,休息一周后随机交叉用药。在每一治疗周最后一天,用药前、用药后2、6、12和24小时同步记录心率、血压、心声阻抗图和心机械图。根据心电图、
Histamine through the H 1 and H 2 receptor-mediated cardiac function have different effects, histamine H 2 blockers whether adverse effects on cardiac function, the evaluation of the three H 2 receptor blockers - cimetidine Effects of Ding, Ranitidine and Famotidine on Hemodynamic Parameters. Methods Ten volunteers were selected as randomized double-blind controlled study. Each person received cimetidine 800mg, ranitidine 300mg, famotidine 40mg or placebo, day 1, treatment for 7 days, a week after the rest randomized medication. At the last day of each treatment week, heart rate, blood pressure, phonocardiogram and cardiogram were recorded simultaneously before treatment, 2, 6, 12 and 24 hours after treatment. According to the electrocardiogram,