西咪替丁对豚鼠正常和缺氧心室肌细胞跨膜电位的影响

• 作 者: 陈础 胡和成 陈庚新 徐学峥
• 机 构: 浙江医科大学生理学教研室,浙江医科大学生理学教研室,浙江医科大学生理学教研室,浙江医科大学生理学教研室,
• 出 处: 浙江医科大学学报
• 发表日期: 1991年03期
• 关键词: 跨膜电位 心室肌细胞 心肌细胞 乳头肌 抗心律失常作用 抗心律失常药 冠状动脉疾病 动作电位 细胞电生理 急性心肌缺血

本文研究西咪替丁(Cim)对正常和缺氧豚鼠心室肌细胞跨膜电位的影响.结果显示,Cim 2.1×10~(-5)mol/L使豚鼠心室乳头肌APD_(50)和APD_(90)从对照的166.4±1.1和200.6±1.1ms分别延长至189.5±1.2和231.3±1.1ms;使缺氧60min时APD_(50)和APD_(90)由119.7±1.4和158.6±1.2分别延长至152.3±1.3和195.7±1.2ms,并使缺氧心肌动作电位其他参数均有所改善.提示Cim对缺氧心室肌具有保护作用,并有抗心律失常作用,其机理可能与Cim减少Ca~(2+)内流入心肌细胞有关

In this paper, the effects of Cim on the transmembrane potential of normal and hypoxic guinea pig ventricular myocytes were studied. The results showed that APD 50 and APD 50 were significantly increased in Cim 2.1 × 10 -5 mol / (90) were prolonged from 166.4 ± 1.1 and 200.6 ± 1.1ms of control to 189.5 ± 1.2 and 231.3 ± 1.1ms, respectively; APD_ (50) and APD_ (90) increased from 119.7 ± 1.4 and 158.6 ± 1.2 To 152.3 ± 1.3 and 195.7 ± 1.2ms, and improved the other parameters of anoxia myocardial action potential.It is suggested that Cim has a protective effect on hypoxic ventricular muscle and has an anti-arrhythmic effect, the mechanism may be related to Cim to reduce Ca ~ (2+) into the myocardial cells