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目的 :研究泽泻对肝硬化门脉高压血流动力学的影响 ,寻求治疗肝硬化门脉高压的理想药物。方法 :采用 40 %四氯化碳诱导大鼠肝硬化门脉高压模型。对肝硬化门脉高压大鼠进行泽泻灌胃治疗 (每日 5 g/kg ,疗程 1个月 ) ,然后测定尿量、门静脉压力、肠系膜上动脉血流量和血管阻力、平均动脉压等血流动力学指标。应用放射免疫法测定泽泻治疗前后血浆肾素和醛固酮水平。以中药丹参作为治疗对照组。结果 :泽泻具有明显利尿作用 ,治疗后可使肝硬化大鼠尿量明显增加 [(12 33± 5 5 5 )∶(31 0 5± 2 4 91)ml/ 2 4h ,P <0 0 1) ],并能够显著减少肠系膜上动脉血流量 [(34 39± 12 2 0 )∶(2 1 96± 4 16 )ml/ (min·kg) ,P <0 0 1) ]和门静脉压力 [(1 90± 0 2 1)∶(1 44± 0 33)kPa ,P <0 0 5 ) ]。泽泻治疗前后血浆肾素、醛固酮水平无明显改变。结论 :泽泻具有明显降低肝硬化门脉压力的作用 ,可能是通过利尿和减少肠系膜上动脉血流量发挥作用。泽泻可作为治疗肝硬化门脉高压的有效药物。
Objective: To study the effect of Alisma on hemodynamics of portal hypertension in liver cirrhosis, and to seek an ideal drug for the treatment of liver cirrhosis and portal hypertension. METHODS: Rat hepatic portal hypertension model was induced by 40% carbon tetrachloride. The liver cirrhosis portal hypertension rats were treated with Alisma (5 g/kg daily for 1 month) and then the urine volume, portal vein pressure, superior mesenteric artery blood flow and vascular resistance, mean arterial pressure, etc. were measured. Hydrodynamic indicators. Radioimmunoassay was used to determine plasma renin and aldosterone levels before and after treatment. The traditional Chinese medicine Danshen was used as a treatment control group. Results: Alisma had obvious diuretic effect, and after treatment, the urine volume of cirrhotic rats increased significantly [(12 33± 5 5 5): (31 0 5 ± 2 4 91) ml/24h, P <0 0 1 ) ], and can significantly reduce the upper mesenteric artery blood flow [(34 39 ± 12 20): (2 1 96 ± 4 16) ml / (min · kg), P <0 0 1)] and portal vein pressure [( 1 90 ± 0 2 1): (1 44 ± 0 33) kPa, P <0 0 5 ). There was no significant change in plasma renin and aldosterone levels before and after treatment. Conclusion: Alisma has the effect of significantly reducing portal hypertension in liver cirrhosis. It may play a role in diuresis and decrease of blood flow in superior mesenteric artery. Alisma can be used as an effective drug for treating portal hypertension in liver cirrhosis.