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目的 探讨血C反应蛋白 (C -reactiveprotein ,CRP)和血尿酸 (uricoacid ,UA)与冠状动脉病变稳定性的关系。方法 测定 2 0 5例初诊为“冠心病、不稳定心绞痛”患者的血清CRP和UA水平 ,并根据冠状动脉造影的结果分为对照组、病变稳定组和病变不稳定组 ,观察血清CRP和UA与冠脉病变稳定性的关系。结果 不稳定病变组CRP水平显著高于稳定病变组 (P <0 0 1) ,两组UA水平比较 (P >0 0 5 )差异无显著性。CRP浓度与冠脉病变不稳定性作直线回归分析 (r =0 45 96,P <0 0 5 ) ,二者呈正相关。UA浓度与冠脉病变不稳定性作直线回归分析 (r =0 5 874,P >0 0 5 ) ,二者无相关性。结论 血CRP水平与不稳定病变呈明显正相关。血UA水平与不稳定病变无明显相关性 ,但在冠心病的发生发展中有一定作用。
Objective To investigate the relationship between C-reactive protein (C-reactive protein) and uricoacid (UA) and the stability of coronary artery disease. Methods Serum levels of CRP and UA in 205 newly diagnosed patients with coronary heart disease and unstable angina were measured and divided into control group, stable group and unstable group according to the results of coronary angiography. Serum levels of CRP and UA Relationship with the stability of coronary artery disease. Results The level of CRP in unstable group was significantly higher than that in stable group (P <0.01). There was no significant difference in UA between the two groups (P> 0.05). Linear regression analysis of CRP concentration and coronary artery instability (r = 0 45 96, P <0 05) showed a positive correlation between them. The linear regression analysis of UA concentration and coronary artery instability (r = 0 5 874, P> 0.05) showed no correlation between them. Conclusion The blood level of CRP is positively correlated with unstable lesions. Blood UA levels and unstable lesions no significant correlation, but in the occurrence and development of coronary heart disease have a role.