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目的 探讨血清肌钙蛋白I(TnI)、肌钙蛋白T(TnT)与风湿性疾病心肌损伤的关系。方法 以固相层析法定性检测2 41例风湿病患者 ,其中系统性红斑狼疮 (SLE)组 67例 ,干燥综合征 (SS)组 3 1例 ,系统性硬化症 (SSc)组 18例 ,多发性肌炎 (PM )组 11例 ,类风湿关节炎 (RA)组 72例 ,强直性脊柱炎 (AS)组 42例的TnI、TnT ,且与正常对照组进行比较 ,其阳性率还与CK -MB阳性率进行比较。结果 除AS组外 ,各组血清TnI、TnT阳性率均较CK -MB阳性率高 ,其中SLE、SSc、RA组有显著性差异。同组血清TnI、TnT阳性率对比没有差异 ,对照组三项检测全部正常。结论 血清TnI、TnT检测可作为判断风湿病心脏损伤的敏感指标 ,起到早期心肌损伤的预警作用 ,以便及早给予保护心脏措施
Objective To investigate the relationship between serum troponin I (TnI), troponin T (TnT) and myocardial damage in rheumatic diseases. Methods A total of 241 rheumatism patients were diagnosed by solid phase chromatography. Among them, 67 were systemic lupus erythematosus (SLE), 31 were SS (SS), 18 were SSc (systemic sclerosis) 11 cases of polymyositis (PM) group, 72 cases of rheumatoid arthritis (RA) group, 42 cases of ankylosing spondylitis (AS) group, TnI, TnT, and compared with the normal control group, the positive rate CK-MB positive rates were compared. Results In addition to AS group, the positive rate of TnI and TnT in serum of each group was higher than that of CK-MB, and there was significant difference between SLE, SSc and RA groups. The same group of serum TnI, TnT positive rate was no difference in the control group, all three tests were normal. Conclusion Serum TnI and TnT can be used as a sensitive indicator of heart damage in patients with rheumatic heart disease and play an early warning role in early myocardial damage so that heart protection measures can be given as soon as possible