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Helium effects on dislocation and cavity formation of Fe-11 wt.% Cr model alloy are investigated.Single-beam (electron) and dual-beam (He+ /e-) irradiations are performed at 350℃ and 400℃ using an ultra-high voltage electron microscope combined with ion accelerators.In-situ observation shows that the growth rate of dislocation loops is reduced in the helium pre-injected specimen.The mean size of cavities decreased in the helium preinjected specimen.The possible mechanisms are discussed.