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作者报道对注射3针乙肝疫苗无反应者、乙型肝炎表面抗体(抗-HBs)水平低于10IU/L 的低反应者和随访过程中抗-HBs 低于此水平的人群加强接种乙肝疫苗后机体的免疫反应性。参试者共212例,其中33例为无反应者,低反应者为12例,随访中抗-HBs 低于10IU/L 者167例。原先接种血源疫苗者(25例5μg、43例10μg、122例20μg)仍接种血源疫苗20μg;22例原先接种重组酵母乙肝疫苗(10μg)仍用相同疫苗。所有受试者均为单剂上肢肌肉注射。148例注射后1～2月采血,64例
The authors report that patients who did not respond to the 3-dose hepatitis B vaccine had lower HBeAg seroconversion (HBs) than 10 IU / L and those with anti-HBs below this level after follow-up The body’s immune reactivity. A total of 212 subjects were included, of whom 33 were nonresponders, 12 were low responders, and 167 were anti-HBs less than 10 IU / L at follow-up. The original vaccinated blood-borne vaccine (25 cases of 5μg, 43 cases of 10μg, 122 cases of 20μg) still inoculated with 20μg of blood-borne vaccine; 22 cases of the original vaccination of recombinant yeast hepatitis B vaccine (10μg) still use the same vaccine. All subjects were single-dose upper extremity intramuscularly. 148 cases of blood collected from January to February after injection, 64 cases