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目的 研究重组GST抗原对水牛的保护性及其防制血吸虫病的效果。方法 在洲垸亚型血吸虫病流行区 ,选择两个村居民役用水牛 ,试验组 96头水牛免疫重组GST抗原 ,对照组 90头水牛不免疫作对照 ;观察两组水牛血吸虫感染率、湖洲感染性钉螺密度等的变化。结果 试验组免疫 2 0个月后检测水牛 5 6头 ,感染率为 5 36 % ,比免疫前 (13 5 4 % )下降了6 0 4 1% ,比对照组同期 (16 6 7% )低 6 7 85 % ,试验组外洲易感地带感染性钉螺密度较免疫前降低了 71.4 3%。居民血吸虫感染率基本无变化。结论 水牛免疫重组GST抗原能产生一定的保护力 ,对降低水牛血吸虫病情有明显作用。
Objective To study the protective effect of recombinant GST antigen on buffaloes and its effect on controlling schistosomiasis. Methods In the epidemic area of embankment subtype of schistosomiasis, two buffaloes serving in the village, buffalo immunized with GST antigen of 96 buffaloes and non-immunized buffaloes of 90 buffaloes in the control group were selected as controls. The infection rates of schistosomiasis, Infectious snail density and other changes. Results In the test group, 56 females were detected after 20 months of immunization, the infection rate was 536%, which was 6 0 4 1% lower than that before immunization (13 5 4%), lower than that of the control group (16 6 7%) In the experimental group, the density of infective snails in the susceptible zone of the continent was 71.4 3% lower than that before immunization. Residents of schistosomiasis infection rate basically no change. Conclusion The buffalo immunized recombinant GST antigen can produce certain protective effect, which has a significant effect on reducing the buffalo schistosomiasis condition.