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目的 :探讨HP感染慢性胃炎及十二指肠溃疡患者血清IL - 8、TNF -α及Gas水平变化与其发病的关系。方法 :选择1 4C -尿素呼气试验阳性及胃镜和病理组织学确诊的 35例慢性胃炎及 30例十二指肠溃疡患者 ,皆采用放射免疫分析测定其血清IL - 8、TNF -α及Gas水平。结果 :慢性胃炎组血清IL - 8、TNF -α及Gas均显著高于正常对照组 ,其血清IL - 8及Gas水平与对照组比较差异极显著 (p <0 0 1)。TNF -α与对照组比较也具统计学意义 (p <0 0 5 )。十二指肠溃疡组则三项指标均极显著高于正常对照组 (p <0 0 1)。两组间比较三项指标亦均呈极显著差异 (p <0 0 1)。结论 :HP感染的慢性胃炎及十二指肠溃疡患者三项指标均呈显著变化 ,证实两种消化系疾病的发生、发展与HP感染密切相关。
Objective: To investigate the relationship between serum IL - 8, TNF - α and Gas levels and their pathogenesis in patients with chronic gastritis and duodenal ulcer after HP infection. Methods: Thirty - five patients with chronic gastritis and 30 patients with duodenal ulcer diagnosed by gastroscopy and histopathology were selected for the determination of serum IL - 8, TNF - α and Gas by radioimmunoassay Level. Results: Serum levels of IL - 8, TNF - α and Gas in chronic gastritis group were significantly higher than those in normal control group. The serum IL - 8 and Gas levels were significantly different from those in control group (p <0.01). TNF-α was also statistically significant compared with the control group (p <0 05). The three indicators of duodenal ulcer group were significantly higher than the normal control group (p <0.01). Three indicators of comparison between the two groups also showed a significant difference (p <0.01). CONCLUSION: The three indicators of chronic gastritis and duodenal ulcer patients with HP infection showed significant changes, confirming the occurrence and development of two kinds of digestive diseases are closely related to HP infection.