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目的分析11 722例已婚女性的宫颈液基细胞学(TCT)筛查结果。方法选取2013年1月-2015年11月在该院进行体检的11 722例已婚女性作为研究对象,均运用TCT技术进行初筛,对于诊断为宫颈上皮不典型鳞状上皮细胞(ASCUS)及以上的患者均进行宫颈多点活检,回顾性分析筛查。结果经TCT筛查,结果显示有95.96%的宫颈细胞学检查结果正常,474例的细胞学检查结果呈阳性,占4.04%。在异常细胞学检查结果中,未明确意义的非典型磷状上皮细胞(ASC-US)有311例,占2.65%,其中ASC-US、非典型鳞状上皮细胞不除外高级病变(ASC-H)、鳞状上皮内低度病变(LSIL)、鳞状上皮内高度病变(HSIL)、腺癌分别占2.65%、0.15%、1.02%、0.21%、0.01%。ASC-H及以上病变经组织活检显示21例为阴性,细胞学检查的假阳性率为12.88%,142例的细胞学检查结果为CIN1及以上程度病变,细胞学检查的诊断准确率为87.12%。TCT筛查阳性的中位年龄为35.87岁,ASC-US+ASC-H、LSIL、HSIL病例中30~49岁年龄段分别占据了78.60%、60.50%、64.00%。除≥60岁年龄段外,ASC-US+ASC-H、LSIL、HSIL 3组患者其他各年龄段对比均无统计学差异(P>0.05)。ASC-US+ASC-H与LSIL病例的平均年龄对比无明显差异,P>0.05;HSIL病例的平均年龄明显高于ASC-US+ASC-H病例和LSIL病例,P<0.05。HSIL病例的平均年龄明显高于ASC-US+ASC-H病例和LSIL病例,P<0.05。结论对已婚女性进行TCT检查检出宫颈异常情况,结合宫颈活检对于宫颈癌前病变及癌变的早期发现、早期治疗具有重大意义。
Objective To analyze the results of cervical liquid-based cytology (TCT) screening in 11 722 married women. Methods A total of 11 722 married women who underwent physical examinations in our hospital from January 2013 to November 2015 were selected as the study subjects. All patients were screened by TCT technique. For the diagnosis of atypical squamous cell carcinoma of cervix (ASCUS) and All of the above patients underwent multi-biopsy of the cervix and retrospectively analyzed and screened. The results of TCT screening, the results showed that 95.96% of cervical cytology findings were normal, 474 cytology results were positive, accounting for 4.04%. Among the abnormal cytological findings, there were 311 cases (2.65%) of undetermined significance of atypical P-type epithelial cells (ASC-US), of which ASC-US and atypical squamous cells were not excepted except for ASC-H ), LSIL, HSIL and adenocarcinoma accounted for 2.65%, 0.15%, 1.02%, 0.21% and 0.01% respectively. Tissue biopsies of ASC-H and above showed that 21 cases were negative, the false positive rate of cytology was 12.88%, the cytological results of 142 cases were CIN1 and above, the diagnostic accuracy of cytology was 87.12% . The median age of TCT screening was 35.87 years old. The age groups of ASC-US + ASC-H, LSIL and HSIL accounted for 78.60%, 60.50% and 64.00% respectively. There were no significant differences in other age groups except for the age group of 60 or older (P> 0.05). There was no significant difference in average age between ASC-US + ASC-H and LSIL (P> 0.05). The mean age of HSIL was significantly higher than that of ASC-US + ASC-H and LSIL (P <0.05). The average age of HSIL cases was significantly higher than that of ASC-US + ASC-H cases and LSIL cases, P <0.05. Conclusions The detection of cervical abnormalities by TCT in married women and cervical biopsy are of great significance for the early detection and early treatment of cervical precancerous lesions and canceration.