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再障的定义根据Heimpel 及Kubaneck 的意见可概括为:“临床应有全血细胞缺乏而外周血细胞未有明显破坏,骨髓及/或髓外造血组织增生低下,没有骨髓纤维化症或恶性肿瘤疾病在骨髓中的浸润.其细胞动力学变化,主要是干细胞贫乏,使造血细胞池中分化及成熟细胞缺乏”.简言之,应排除其它原因引起的全血细胞减少症。再障的发病机理已从三方面探索:造血干细胞缺乏、造血微环境(HIM)损害以及机体免疫机制
According to Heimpel and Kubaneck’s opinion, the definition of aplastic anemia can be summarized as follows: “There should be clinically complete lack of whole blood cells without obvious destruction of peripheral blood cells, low proliferation of bone marrow and / or extramedullary hematopoietic tissues, absence of myelofibrosis or malignant tumors Bone marrow infiltration .Changes in their cell dynamics, mainly stem cell depletion, the hematopoietic cells in the pool and the lack of mature cells. ”In short, should be ruled out of other causes of pancytopenia. The pathogenesis of aplastic anemia has been explored from three aspects: lack of hematopoietic stem cells, hematopoietic microenvironment (HIM) damage and immune mechanisms