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目的探讨慢性阻塞性肺疾病(COPD)与幽门螺杆菌(HP)感染的关系。方法选择2010年1月~2014年1月魏县第二人民医院收治的COPD患者110例作为COPD组,60例健康体检者作为对照组,采用酶联免疫法检测两组患者IL-6、IL-17及HP-Ig G抗体水平,对COPD患者进行第1秒最大呼气量(FEV1)、用力肺活量(FVC)、FEVl/FVC值、氧分压(PO2)、二氧化碳分压(PCO2)和血氧饱和度(Sa O2)检测。结果 COPD组HP-Ig G检测阳性率高于对照组(70.9%vs46.7%,χ2=9.720,P=0.002);COPD组血清IL-6、IL-17水平及HP-Ig G滴度均高于对照组[(11.75±4.16)pg/m L vs(5.38±2.11)pg/m L,(7.08±3.62)pg/m L vs(3.86±1.80)pg/m L,(45.77±23.53)U/m L vs(32.50±22.07)U/m L,t=3.591~11.098,P均=0.000],COPD组HP-Ig G阳性患者血清IL-6、IL-17水平及HP-Ig G滴度均高于HP-Ig G阴性患者[(13.16±4.55)pg/m L vs(8.65±4.06)pg/m L,(8.73±3.87)pg/m L vs(6.16±3.41)pg/m L,(52.88±21.39)U/m L vs(13.61±5.78)U/m L,t=3.270~10.208,P=0.000~0.001],HP-Ig G阳性组FEV1、FVC、FEV1/FVC、PCO2、Sa O2均低于HP-Ig G阴性组[(1.24±0.41)L vs(1.49±0.46)L、(2.24±0.51)L vs(2.53±0.48)L,(49.51±5.42)%vs(56.36±6.84)%,(54.27±6.12)mm Hg vs(61.18±6.09)mm Hg,(84.27±11.06)%vs(89.64±10.82)%,t=2.327~5.886,P=0.000~0.022],PCO2高于HP-Ig G阴性组[(49.41±5.28)mm Hg vs(47.04±5.13)mm Hg,t=2.156,P=0.033],差异均有统计学意义。结论 HP感染可影响COPD患者呼吸功能,与COPD的进展存在密切联系。
Objective To investigate the relationship between chronic obstructive pulmonary disease (COPD) and Helicobacter pylori (HP) infection. Methods One hundred and seventy COPD patients admitted to the Second People’s Hospital of Weixian from January 2010 to January 2014 were selected as the COPD group and 60 healthy subjects as control group. The levels of IL-6 and IL-6 (FEV1), forced vital capacity (FVC), FEV1 / FVC, PO2, PCO2 and COP2 in COPD patients and Oxygen saturation (Sa O2) test. Results The positive rate of HP-Ig G in COPD group was higher than that in control group (70.9% vs46.7%, χ2 = 9.720, P = 0.002). The levels of IL-6, IL- Which was significantly higher than that in the control group [(11.75 ± 4.16) pg / m L vs. (5.38 ± 2.11) pg / m L, (7.08 ± 3.62 pg / m L vs 3.86 ± 1.80 pg / m L, (45.77 ± 23.53) The serum level of IL-6 and IL-17 in HP-Ig G positive patients and the serum levels of HP-Ig G in the COPD group were significantly lower than those in the HP group (P <0.01) (13.16 ± 4.55) pg / m L vs (8.65 ± 4.06) pg / m L, (8.73 ± 3.87) pg / m L vs. (6.16 ± 3.41 pg / m L) (52.88 ± 21.39) U / m L vs (13.61 ± 5.78) U / m L, t = 3.270-10.208, P = 0.000-0.001] .The positive rates of FEV1, FVC, FEV1 / SaO2 were lower than those in HP-Ig G negative group [(1.24 ± 0.41) L vs (1.49 ± 0.46) L, (2.24 ± 0.51) L vs (2.53 ± 0.48) L, (49.51 ± 5.42)% vs (56.36 ± 6.84)%, (54.27 ± 6.12) mm Hg vs (61.18 ± 6.09) mm Hg, (84.27 ± 11.06)% vs (89.64 ± 10.82)%, t = 2.327 ~ 5.886, P = 0.000 ~ 0.022] HP-Ig G negative group [(49.41 ± 5.28) mm Hg vs (47.04 ± 5.13) mm Hg, t = 2.156, P = 0.033] .The differences were statistically significant. Conclusion HP infection can affect respiratory function in patients with COPD, and is closely related to the progress of COPD.