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第3代胃肠促动力药西沙必利.具有作用范围广,有不同于前两代胃肠动力药的特点.本品可作用于全胃肠道,无锥体外系及内分泌和胆碱能性的不良反应,能增加整个消化道推进性的运动,没有直接拟胆碱和抗多巴胺作用.1995年以来我们对应用西沙必利治疗功能性便秘60例患者进行观察,临床显示了较满意的效果.病例 选择便秘患者60例,男43例,女17例,年龄为25～69a.首先排除器质性病变,排除内分泌和代谢性疾病.病人具有大便燥结、排除费力,病程5mo～7a,每次排便时间及间隔天数较以前增加1倍以上.治疗方法 停服致泻剂5d后服用西沙必利5mg(西安杨森制药公司生产.)tid,5wk为一疗程.无效改服10mg,tid.疗效判断 无效:为排便习惯无变化;有效:为
The third generation of gastrointestinal motility drug cisapride has a wide range of effects, different from the previous two generations of gastrointestinal motility drug characteristics. This product can be used in the whole gastrointestinal tract, without extrapyramidal and endocrine and cholinergic Sexual adverse reactions, can increase the entire gastrointestinal propulsive exercise, there is no direct choline and anti-dopamine effect.Since 1995 we use cisapride in patients with functional constipation observed in 60 patients, the clinical showed a more satisfactory Results 60 cases of constipation patients selected, 43 males and 17 females, aged 25 ~ 69a. First ruled out organic disease, excluding endocrine and metabolic diseases. Patients with dry stool, eliminating laborious, duration of 5mo ~ 7a , Each defecation time and interval days increased more than 1 times before the treatment of stopping diarrhea agent 5d after taking cisapride 5mg (Xi’an Janssen Pharmaceutical Company.) Tid, 5wk for a course of treatment. Invalid service 10mg, tid Invalid efficacy judgment: No change in bowel habits; Effective: Yes