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慢性氟中毒是世界上分布较广泛的一种地方性疾病,除累及牙齿、骨骼外,还对非骨相的多种组织和器官有损害作用[1]。肾脏是氟的主要排泄器官,当机体摄入过量氟超过肾的排泄能力时,导致氟在体内蓄积,肾脏含氟量明显增多[2]。氟中毒引起大鼠肾脏功能及病理形态改变已有较多报道,而
Chronic fluorosis is a type of endemic disease widely distributed in the world. In addition to involving teeth and bones, it also has a detrimental effect on non-bony tissues and organs [1]. Kidney is the main organ of excretion of fluoride, when the body excessive intake of fluoride over the renal excretion capacity, resulting in the accumulation of fluoride in the body, significantly increased the amount of fluoride in the kidneys [2]. Fluorosis caused renal function and pathological changes in rats have been reported more