The testis-specifically expressed gene Trim69 is not essential for fertility in mice

• 作 者: Xi He Wenxiu Xie Huiling Li Yi
• 机 构: StateKeyLaboratoryofReproductiveMedicine
• 出 处: 生物医学研究杂志:英文版
• 发表日期: 2021年1期
• 关键词: Trim69 gene knockout SPERMATOGENESIS E3 ubiquitin ligase male fertility
• 基金项目: supported by the National Key Research and Development Program of China(No.2018YFC1003503-2,No.2017YFA0103803,and No.2016YFA0500903),the National Natural Science Foundation of China(No.31890784)

Protein ubiquitination is essential for diverse cellular functions including spermatogenesis.The tripartite motif(TRIM)family proteins,most of which have E3 ubiquitin ligase activity,are highly conserved in mammals.They are involved in important cellular