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本文综述近年来胃粘膜壁细胞(Parietal cell,简称PC)体外研究进展。主要介绍PC分离、纯化、生物学鉴定技术,PC受体功能、PC受到刺激时形态、代谢及膜通透性变化。利用体外PC这个模型,对于研究胃酸的分泌和调控,以及抑制泌酸药物的作用机理具有重要价值,同时,对于研究中药的抗酸作用也是有用的模型。本文还讨论了PC功能检测以及研究趋势。
This article reviews recent advances in in vitro studies of gastric parietal cells (PCs). Mainly introduce PC separation, purification, biological identification technology, PC receptor function, PC morphology, metabolism and membrane permeability changes when stimulated. The use of the in vitro PC model is of great value for the study of gastric acid secretion and regulation, as well as the mechanism of action of the inhibition of oxyntic drugs. At the same time, it is also a useful model for the study of the anti-acid function of traditional Chinese medicines. This article also discusses PC function detection and research trends.