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《美国医学会杂志》第241卷第22期(1979年6月1日)第2424页刊载编辑部社论:健康人因病而服药后造成的死亡中,大多数与服用肝素有关,但肝素的结构组成尚未准确地确定。由牛肺及猪肠的肥大细胞制成的肝素制剂,其纯度及抗原作用不同。由于肝素活性决定于血浆及血小板抗凝血酶之间的相互作用,肝素在体内的作用就很难预测或明确,而血小板抗凝血酶水平的测定一部分是通过其正常或异常凝血中的消耗量所决定的。治疗量的肝素
241, No. 22, September 24, 1979 2424 The editorial board editorials that most of the deaths caused by healthy people taking medicine after taking the medicine are related to taking heparin, but the heparin The composition of the structure has not been precisely defined. Heparin preparations made from mast cells of bovine lung and porcine intestine have different purities and antigens. Since heparin activity depends on the interaction between plasma and platelet antithrombin, the effect of heparin in the body is difficult to predict or clarify, and the determination of platelet antithrombin levels is partly due to its depletion in normal or abnormal coagulation The amount of the decision. Therapeutic amount of heparin