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目的研究磷酸川芎嗪的大鼠在体肠吸收性质。方法运用单向灌流模型、采用HPLC法对药物的质量浓度进行检测,分别研究灌流速度、药物质量浓度、pH值以及吸收部位对磷酸川芎嗪吸收的影响。结果灌流速度和pH值对磷酸川芎嗪的吸收速率常数(ka)和表观吸收系数(Papp)有显著性影响;药物质量浓度对ka和Papp无显著性影响;小肠各段间药物吸收的ka和Papp无显著性差异,但与回肠段相比吸收明显增大。结论磷酸川芎嗪的吸收速率不受药物质量浓度的影响,而与灌流速度、灌流液的pH值和肠段部位有关。药物在全肠道吸收较好,吸收窗主要在小肠,且小肠内无明显的特定吸收部位。
Objective To study the intestinal absorption properties of rat tetramethylpyrazine phosphate. Methods One-way perfusion model and HPLC method were used to detect the drug concentration. The effects of perfusion rate, drug concentration, pH value and absorption sites on the absorption of tetramethylpyrazine phosphate were studied. Results The perfusion rate and pH had a significant effect on the absorption rate constant (ka) and apparent absorption coefficient (Papp) of ligustrazine phosphate; the drug concentration had no significant effect on ka and Papp; drug absorption in the small intestine There was no significant difference between Papp and Papp, but it was significantly higher than that of ileum. Conclusion The absorption rate of ligustrazine phosphate is not affected by the drug concentration, but related to the perfusion rate, the pH of the perfusate, and the intestinal segment. The drug absorbed better in the whole intestine, the absorption window was mainly in the small intestine, and there was no obvious specific absorption site in the small intestine.