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目的探讨不同HBV-DNA载量乙肝患者血清超敏C反应蛋白(hs-CRP)测定的临床意义。方法对180例乙肝患者的血清标本采用PCR技术检测HBV-DNA,将其阳性标本按临床诊断分组,同时按HBV-DNA拷贝数分成4组。免疫投射比浊法测定hs-CRP活性。结果在乙肝HBV-DNA阳性的各组患者中,其hs-CRP活性均增高,与健康对照组比较,差异有统计学意义(P均<0.01),尤其以肝硬化组增高最明显;不同HBV-DNA载量的乙肝患者血清hs-CRP含量差异无统计学意义(P>0.05)。结论乙肝患者具有不同程度的肝细胞损伤,检测hs-CRP对肝细胞损伤有意义,但其含量与乙肝病毒复制程度无关。
Objective To investigate the clinical significance of serum hs-CRP in patients with different HBV-DNA loading hepatitis B patients. Methods Serum samples from 180 hepatitis B patients were tested for HBV-DNA by PCR. The positive samples were divided into four groups according to the clinical diagnosis, and divided by HBV-DNA copy number. Immunostaining turbidimetric assay hs-CRP activity. Results The hs-CRP activity in HBV-DNA positive group was higher than that in healthy control group (P <0.01), especially in cirrhosis group. There was no significant difference in serum hs-CRP levels between two groups (P> 0.05). Conclusion Hepatitis B patients have different degrees of hepatocellular injury, detection of hs-CRP on liver cell damage is meaningful, but its content has nothing to do with the degree of hepatitis B virus replication.