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作者研究了硝苯吡啶治疗高血压的近期疗效、剂量和效果的关系,对静脉的作用,对肾上腺素能神经反射的影响以及对不同类型和不同严重程度高血压的治疗效果。方法:45例高血压患者,男性32例,女性13例,年龄25～65岁。原发性高血压25例,肾血管性高血压10例,慢性肾盂肾炎致高血压10例。所有患者停止任何治疗二周,研究期间患者不服用其他药物;进标准饮食,含钠100mEq和钾80mEq。研究开始第一周,服用安慰剂,如舒张压>100mmHg,则于第七天并用硝苯吡啶治疗,均舌下含用。研究系采用双肓法进行。对15例原发性高血压患者,研究了
The authors studied the short-term efficacy of nifedipine in the treatment of hypertension, the relationship between dose and effect, effects on veins, effects on adrenergic reflexes, and effects on hypertension of different types and severity. Methods: 45 cases of hypertension, 32 males and 13 females, aged 25 to 65 years. 25 cases of essential hypertension, renal vascular hypertension in 10 cases, chronic pyelonephritis caused by hypertension in 10 cases. All patients discontinued any treatment for two weeks, during which time the patient did not take other medications; into a standard diet containing 100 mEq of sodium and 80 mEq of potassium. The first week of the study, placebo, such as diastolic blood pressure> 100mmHg, on the seventh day and nifedipine treatment, are sublingual. The research department uses the double method. Fifteen patients with essential hypertension were studied