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目的探讨放疗同步联合多西他赛、顺铂和5-氟尿嘧啶(5-Fu)化疗方案(TPF方案)以及联合顺铂和5-Fu化疗方案(PF方案)治疗食管癌术后纵隔淋巴结转移的疗效较。方法选取2007年1月至2011年12月间收治的120例食管癌术后纵隔淋巴结转移的患者,采用简单随机抽样法分为观察组和对照组,每组60例。观察组患者放疗同步联合TPF化疗方案,对照组患者采用放疗同步联合PF化疗方案。比较两组患者的不良反应及近期疗效,并对患者预后进行分析。结果两组患者放化疗不良反应发生率和治疗总有效率差异均无统计学意义(均P>0.05);两组患者1年生存率差异无统计学意义(P>0.05),而观察组患者3年生存率明显高于对照组,差异有统计学意义(P<0.05);对照组患者复发率明显高于观察组,差异有统计学意义(P<0.05)。结论放疗同步TPF化疗方案治疗食管癌术后纵隔淋巴结转移的耐受性较好,远期生存率较高,值得临床推广。
Objective To investigate the effect of radiotherapy combined with docetaxel, cisplatin and 5-fluorouracil chemotherapy (TPF) and cisplatin combined with 5-Fu chemotherapy (PF regimen) in the treatment of postoperative mediastinal lymph node metastasis of esophageal cancer More effective. Methods A total of 120 patients with postoperative mediastinal lymph node metastasis from January 2007 to December 2011 were randomly divided into observation group and control group with 60 cases in each group. Patients in the observation group received radiotherapy combined with TPF chemotherapy and patients in the control group received radiotherapy combined with PF chemotherapy. Adverse reactions and short-term efficacy of the two groups were compared, and the prognosis of patients was analyzed. Results There was no significant difference between the two groups in the incidence of adverse reactions and the total effective rate of treatment (all P> 0.05). There was no significant difference in one-year survival rate between the two groups (P> 0.05) 3-year survival rate was significantly higher than the control group, the difference was statistically significant (P <0.05); the recurrence rate of the control group was significantly higher than the observation group, the difference was statistically significant (P <0.05). Conclusion Radiotherapy concurrent TPF chemotherapy regimen in patients with mediastinal lymph node metastasis after esophageal cancer is better tolerated, long-term survival rate is higher, worthy of clinical promotion.