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表皮干细胞在损伤修复中的作用日益得到人们的重视,而它的分裂方式、增殖活性对其完成上皮修复至关重要。现已证实,表皮干细胞的增殖分化受到诸如其表面受体、微环境等多因素的影响。整合素主要分布在表皮干细胞的胞膜上,不仅起黏附作用,同时也介导胞外与胞内的双向信息传递,它对表皮干细胞的增殖、迁移及分化等多方面均有显著的调控作用,且整合素表达异常导致表皮干细胞活性降低、分裂方式改变,与多种疾病的发生密切相关。该文就近年来整合素的表达与分布,其调控表皮干细胞增殖分化的作用机制以及整合素异常与疾病的关系等作一综述。
The role of epidermal stem cells in wound healing is gaining more and more attention, and its mode of division and proliferative activity are crucial for its completion of epithelial repair. It has been confirmed that the proliferation and differentiation of epidermal stem cells are influenced by many factors such as their surface receptors, microenvironment and so on. Integrins are mainly distributed on the membrane of epidermal stem cells, not only play an adhesion role, but also mediate two-way information transmission between extracellular and intracellular, which has a significant regulatory effect on the proliferation, migration and differentiation of epidermal stem cells , And abnormal expression of integrin lead to decreased activity of epidermal stem cells, changes in the way of division, and a variety of diseases are closely related. This article reviews the expression and distribution of integrins in recent years, and their roles in regulating the proliferation and differentiation of epidermal stem cells and the relationship between integrin abnormalities and diseases.