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Sarcophytol-A(1)是1979年由Kobayashi等首次从海洋软珊瑚(Sarcophyton glaucum)中分离鉴定出的一种含羟基的西松烷(Cembrane)型大环二萜天然产物.生物活性试验表明它具有显著的抗肿瘤活性.我们曾首次完成了(±)-Sarcophytol-A苄醚衍生物(2)和其异构体Isosarcophytol-A(3)的全合成,日本学者也先后报道了1的全合成,但所用方法均有合成路线长和总收率较低的不足,我们以甲基异丙基酮(4)和全反式法
Sarcophytol-A (1) is a natural product of hydroxyethyl-containing macrocyclic diterpene isolated from marine soft corals (Sarcophyton glaucum) by Kobayashi et al. In 1979. Biological activity tests show that it has Significant antitumor activity.We have completed the total synthesis of (±) -Sarcophytol-A benzyl ether derivative (2) and its isomer Isosarcophytol-A (3) for the first time, and Japanese scholars also reported the total synthesis of 1 , But the methods used have long synthetic route and low total yield, we use methyl isopropyl ketone (4) and all-trans method