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采用淬火和模拟退火两种分子动力学的方法对亮氨酸脑啡肽进行了构象搜索，发现了多个Gly－Pheβ－Ⅱ’转角的低能构象．计算结果表明，高温淬火和模拟退火两者结合起来可以有效地寻找低能构象．
The conformational search of leucine enkephalin was carried out by two kinds of molecular dynamics methods, quenching and simulated annealing, and the low-energy conformations of multiple Gly-Pheβ-Ⅱ ’corners were found. The calculated results show that both high temperature quenching and simulated annealing can effectively search for low energy conformations.