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1994年,日本献血总人数为660万,其中献200ml全血者占41.8％,而献400ml全血占35.6％,单采供者占22.5％。所献血液中,制备约835万袋血液成分用于临床输血。除用作血成分外,72万升原料血浆被用于制备血浆衍生物,因此日本的因子Ⅷ已达到自给自足。虽然输血已相当安全,但是仍然存在获得性输血相关GVHD(TA-GVHD)或窗口期血液感染HIV的危险。为避免输血的不良反应,提倡减少同种异体输血
In 1994, the total number of blood donors in Japan was 6.6 million, of which 41.8% were for 200 ml whole blood, 35.6% for 400 ml whole blood, and 22.5% for single collectors. In the donated blood, approximately 8.35 million bags of blood components were prepared for clinical blood transfusions. In addition to its use as a blood component, 720,000 liters of raw plasma was used to prepare plasma derivatives, so Japan’s Factor VIII has reached self-sufficiency. Although blood transfusions are quite safe, there is still the risk of acquired transfusion-associated GVHD (TA-GVHD) or window-infected blood being infected with HIV. In order to avoid adverse reactions to blood transfusion, we advocate reducing allogeneic blood transfusions.