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目的:观察左卡尼汀治疗小儿轮状病毒感染所致心肌损害的临床疗效。方法:轮状病毒肠炎合并心肌损害患儿72例,按就诊顺序分为治疗组38例和对照组34例。两组患儿均给予纠正脱水,酸中毒和电解质紊乱等对症治疗,治疗组在此基础上加用左卡尼汀,对照组予大剂量维生素C、维生素E、辅酶Q_(10),疗程均为14 d。观察治疗前后患儿心肌酶谱、肌钙蛋白的改变情况和治疗有效率。结果:两组患儿治疗前心肌酶水平相似且均高于正常值,治疗后心肌酶水平均显著下降(P<0.05),且治疗组较对照组降低更明显(P<0.05);两组心肌肌钙蛋白Ⅰ改善率比较差异无统计学意义(P>0.05);治疗组与对照组有效率分别为94.74%和76.47%,差异有统计学意义(P<0.05)。结论:左卡尼汀对小儿轮状病毒肠炎合并心肌损害具有良好的临床疗效,安全性好。
Objective: To observe the clinical effect of levocarnitine on myocardial damage caused by rotavirus infection in children. Methods: Seventy-two children with rotavirus enteritis and myocardial damage were divided into treatment group (38 cases) and control group (34 cases). Two groups of children were given symptomatic treatment of dehydration, acidosis and electrolyte disorders, the treatment group on this basis with levocarnitine, the control group to high-dose vitamin C, vitamin E, coenzyme Q_ (10), treatment were For 14 days. Before and after treatment to observe myocardial enzymes, troponin changes and treatment efficiency. Results: The levels of myocardial enzymes before treatment in both groups were similar and higher than those in the normal group, and the levels of myocardial enzymes decreased significantly after treatment (P <0.05), and the treatment group decreased more significantly than the control group (P <0.05) There was no significant difference in the improvement rate of cardiac troponin Ⅰ (P> 0.05). The effective rates of treatment group and control group were 94.74% and 76.47%, respectively, with statistical significance (P <0.05). Conclusion: L-carnitine has good clinical efficacy and safety for infantile rotavirus enteritis complicated with myocardial damage.