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目的:分析参附注射液治疗重度脓毒血症的效果及影响因素,为进一步提高参附注射液的临床应用提供参考依据。方法:收集我院ICU治疗的168例重度脓毒血症患者,以治疗过程中全程加用参附注射液的患者为治疗组(82例),以未加用者为对照组(86例),观察参附注射液治疗重度脓毒血症的效果及应用Logistic回归分析其影响因素。结果:以治疗7 d为观察点,治疗组好转45例,迁延22例,死亡15例;对照组好转35例,迁延25例,死亡26例,两组比较,差异有统计学意义(P<0.05);两组首测APACHEII评分比较,差异无统计学意义(P>0.05),治疗组治疗3 d时的APACHEII评分明显低于对照组,差异有统计学意义(P<0.05)。Logistic回归分析显示APACHEII评分、SIRS评分、降钙素原(PCT)等是提高脓毒血症疗效的主要影响因素。结论:参附注射液治疗重度脓毒血症有较好疗效,临床应用应注意患者APACHEII评分、SIRS评分及PCT水平等的影响。
Objective: To analyze the effect and influencing factors of Shenfu injection in treating severe sepsis, and to provide a reference for further improving the clinical application of Shenfu injection. Methods: A total of 168 patients with severe sepsis were collected in ICU of our hospital. The patients in the treatment group were treated with Shenfu injection (82 cases) and the control group (86 cases) , Observe the effect of Shenfu injection in treating severe sepsis and analyze its influential factors by Logistic regression. Results: On the 7th day of treatment, the treatment group improved in 45 cases, delayed in 22 cases and died in 15 cases. The control group improved in 35 cases, delayed in 25 cases and died in 26 cases. There was significant difference between the two groups (P < 0.05). There was no significant difference in APACHEII score between the two groups (P> 0.05). The APACHEII score of the treatment group at 3 d after treatment was significantly lower than that of the control group (P <0.05). Logistic regression analysis showed that APACHEII score, SIRS score, procalcitonin (PCT) and so on were the main factors to improve the curative effect of sepsis. Conclusion: Shenfu injection is effective in treating severe sepsis. The clinical application should pay attention to the influence of APACHEII score, SIRS score and PCT level.