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Objective: To screen abnormally expressed lncRNAs in peripheral blood mononuclear cells from patients with COPD. Methods: The peripheral blood of 3 COPD patients and 3 normal controls were collected from our hospital, mononuclear cells were isolated, RNA was extracted and then transcriptome sequencing was performed. The expression difference between the two groups of samples was calculated based on p 1.Plot the difference lncRNA heat map and volcano map. The Lncpro database may predict mRNAs regulated by differential lncRNA, and perform the GO function and KEGG signaling clustering. Results: There were 67 lncRNAs between the COPD group and the control group that met the difference of p 1, of which 33 were up-regulated and 34 were down-regulated. Between the two groups. The target genes are mainly enriched in GO functions: regulatory functions of multicellular biological processes, regulatory functions of development processes, structured morphogenesis functions, system development functions, and development process functions. Target genes are mainly enriched in KEGG signaling pathways: multi-species apoptotic pathway, TGF-β signaling pathway, complement and coagulation cascade pathway, colorectal cancer pathway and apoptosis pathway. Conclusion: Our results provide general information and possible regulatory functions and pathways of lncRNA expression changes in peripheral blood mononuclear cells of COPD, which may help clarify the underlying mechanism of COPD.