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目的观察单用二甲双胍与二甲双胍联合阿卡波糖对2型糖尿病(type 2diabetes mellitus,T2DM)降糖作用的临床疗效。方法对2010年1～10月就诊有典型易饥多食的T2DM患者45例,随机分为二甲双胍组20例和二甲双胍联合阿卡波糖25例,疗程12周。结果二甲双胍组与二甲双胍联合阿卡波糖组治疗后对患者的饥饿感和食量改善差异有统计学意义(P<0.05),空腹及餐后血糖差异(P<0.01)、空腹血糖达标比例差异(P<0.01)、餐后血糖达标比例差异(P<0.05)均有统计学意义。结论二甲双胍联合阿卡波糖能显著改善T2DM患者的食欲及食量,从而明显降低空腹及餐后血糖。
Objective To observe the clinical effect of metformin and metformin combined with acarbose on type 2 diabetes mellitus (T2DM) hypoglycemic effect. Methods From January to October 2010, 45 cases of T2DM patients who had typical familial hyperactivity were randomly divided into metformin group (n = 20) and metformin combined with acarbose (n = 25) for 12 weeks. Results After treatment with metformin and metformin, the patients’ hunger and appetite were significantly improved (P <0.05), fasting and postprandial blood glucose (P <0.01), fasting blood glucose (% P <0.01), postprandial blood glucose compliance ratio difference (P <0.05) were statistically significant. Conclusion Metformin combined with acarbose can significantly improve the appetite and food intake of T2DM patients, thus significantly reducing fasting and postprandial blood glucose.