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目的：探讨增殖细胞核抗原（ＰＣＮＡ）表达与喉癌生物学行为的相关性。方法：采用流式细胞免疫法检测４０例喉鳞状细胞癌患者ＰＣＮＡ的表达，同时检测８例癌旁组织作为对照。结果：高中分化鳞癌与低分化鳞癌差异有高度显著性（Ｐ＜０．０１），淋巴结转移阳性组与阴性组差异有显著性 （Ｐ＜０．０５），早期组（Ⅰ，Ⅱ）与晚期组（Ⅲ，Ⅳ）差异无显著性（Ｐ＞０／０５），癌组织与癌旁组织间ＰＣＮＡ指数差异有高度显著性（Ｐ＜０．００１）。结论：ＰＣＮＡ表达与喉癌的病理分级、淋巴结转移呈显著正相关，与临床分期无关，ＰＣＮＡ高表达是喉癌的重要生物学特征。
Objective: To investigate the correlation between the expression of proliferating cell nuclear antigen (PCNA) and the biological behavior of laryngeal cancer. Methods: The expression of PCNA in 40 cases of laryngeal squamous cell carcinoma was detected by flow cytometry, and 8 cases of paracancerous tissues were detected as control. Results: There was a significant difference between high grade differentiated squamous cell carcinoma and poorly differentiated squamous cell carcinoma (P <0.01). There was a significant difference between positive group and negative lymph node metastasis group (P <0.05) There was no significant difference between the two groups (P> 0.05), but there was no significant difference between the two groups (P> 0.05). There was a significant difference between PCNA index and adjacent tissues (P <0.001). Conclusion: The expression of PCNA has a positive correlation with the pathological grade and lymph node metastasis of laryngeal carcinoma. It has no relationship with clinical stage, and high expression of PCNA is an important biological characteristic of laryngeal cancer.