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目的观察不同中药注射剂对脑梗死大鼠急性期治疗的作用。方法采用Longa线栓法制作脑梗死大鼠模型。实验大鼠按照要求随机分为5组,即假手术组、模型对照组、黄芪组、丹参组、醒脑静组。分别予以腹腔注射0.9%NaCl溶液、0.9%NaCl溶液、黄芪注射液、丹参注射液、醒脑静注射液。观察比较各组大鼠的死亡率、神经功能缺损评分和脑组织梗死体积。结果各组24h死亡率较模型组显著减少,但2d时只有丹参组死亡率较模型组减少,差异有统计学意义(P<0.01),其他各组和模型组无明显差异。丹参组3d后神经功能缺损评分较模型组显著改善,醒脑静及黄芪组和模型组比较无明显差异。丹参组脑梗死面积较模型组显著减少,醒脑静和黄芪组有一定减轻,但无显著差异。结论不同中药注射剂用于脑梗死急性期的治疗,对于降低早期死亡率均有一定功效。而在改善神经功能和减少梗死面积方面,以丹参注射液治疗则更具优势。
Objective To observe the effect of different traditional Chinese medicine injections on the acute phase of cerebral infarction in rats. Methods The rat model of cerebral infarction was made by Longa suture method. The rats were randomly divided into 5 groups according to the requirements, namely sham operation group, model control group, Astragalus group, Salvia group, Xingnaojing group. The rats were given intraperitoneal injection of 0.9% NaCl solution, 0.9% NaCl solution, Astragalus injection, Salvia injection, Xingnaojing injection. The mortality, neurological deficit scores and infarct volume of the rats in each group were observed and compared. Results The 24-h mortality rate in each group was significantly lower than that in the model group, but only the mortality in the Salvia miltiorrhiza group was lower than that in the model group at 2 days (P <0.01). There was no significant difference between the other groups and the model group. Danshen group 3d after neurological deficit score significantly improved compared with the model group, Xingnaojing and Astragalus group and the model group no significant difference. Salvia group cerebral infarction area significantly reduced compared with the model group, Xingnaojing and Astragalus group had some relief, but no significant difference. Conclusion Different Chinese medicine injection for the treatment of acute cerebral infarction, have some effect to reduce the early mortality rate. In improving neurological function and reduce the infarct size, the treatment of Salvia injection is more advantageous.