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目的:应用高效液相色谱法比较芍药苷和芍药苷亚硫酸酯的代谢产物。方法:将2组健康Wistar大鼠分别按500 mg·kg-1灌胃给予芍药苷和芍药苷亚硫酸酯,于给药前及给药后5,15,30,45,60,90,120,180,240 min由眼眶静脉丛采血,血样经预处理后注入高效液相色谱进行分析。结果:芍药苷组不出现芍药苷亚硫酸酯的峰,芍药苷的体内浓度大约在45 min达到最大值,未知代谢产物X在45 min左右达到最大值;芍药苷亚硫酸酯组也会出现芍药苷的峰,该峰在30 min左右达到最大值,芍药苷亚硫酸酯峰和未知代谢产物X均在30 min左右达到最大值,但此组在给药3 h时已经检测不到芍药苷。结论:大鼠在给予芍药苷亚硫酸酯单体后在体内会部分转化为芍药苷,然而,芍药苷亚硫酸酯不会完全转化为芍药苷,应该适当控制用硫磺熏蒸芍药。
OBJECTIVE: To compare the metabolites of paeoniflorin and paeoniflorin sulfite with high performance liquid chromatography. Methods: Paeoniflorin and paeoniflorin sulfite were given orally to two groups of healthy Wistar rats by intragastric administration at 500 mg · kg-1, respectively. Before and 5, 15, 30, 45, 60, 90, 120, 180 and 240 min after administration, Orbital venous plexus blood sampling, pretreatment of blood samples by high performance liquid chromatography analysis. Results: Paeoniflorin group does not appear paeoniflorin sulfite peaks, the concentration of paeoniflorin in about 45 min to reach the maximum, the unknown metabolite X reached a maximum at 45 min; paeoniflorin sulfite group will also appear peony Glycosides peak, the peak reached the maximum in about 30 min, paeoniflorin sulfite peak and unknown metabolites X reached the maximum in about 30 min, but the group 3 h after administration has been detected paeoniflorin. CONCLUSION: Papers will be partially converted to paeoniflorin in rats after administration of paeoniflorin sulfite monomer. However, paeoniflorin sulfite will not be completely converted to paeoniflorin. Paeoniflorin should be properly controlled with sulfur.