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目的:探讨CTLA4基因启动子区-1722 T/C(rs733618)多态性与中国湖北汉族人群溃疡性结肠炎(UC)的相关性。方法:采用PCR-限制性片段长度多态性方法(PCR-RFLP),对471例中国汉族人群(UC:143例,对照者:328例)进行CTLA4基因-1722位点多态性检测。结果:UC患者CTLA4基因-1722位点C等位基因和T/C+C/C基因型频率与正常对照组相比,差异无统计学意义(34.6%比35.2%,P=0.860,OR=1.027,95%CI=0.767-1.374;60.8%比53.4%,P=0.133,OR=0.736,95%CI=0.494-1.098);-1722T/C基因多态性与UC临床表型无显著相关性。结论:CTLA4基因启动子区-1722T/C基因多态性与中国汉族UC无显著相关性。
Objective: To investigate the association between -1722 T / C (rs733618) polymorphism in CTLA4 promoter region and ulcerative colitis (UC) in Chinese Han population of Hubei province. Methods: PCR-RFLP was used to detect polymorphism of CTLA4 gene -1722 locus in 471 Chinese Han population (UC: 143 cases, control: 328 cases). Results: There was no significant difference in the frequency of C allele and T / C + C / C genotype between the -1722 site of CTLA4 gene and the control group (34.6% vs. 35.2%, P = 0.860, OR = 1.027, 95% CI = 0.767-1.374; 60.8% vs 53.4%, P = 0.133, OR = 0.736, 95% CI = 0.494-1.098); - There was no significant correlation between the 1722T / C polymorphism and the clinical phenotype of UC . Conclusion: The polymorphism of -1722T / C gene in CTLA4 promoter region has no significant correlation with UC in Chinese Han population.