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目的:了解女性泌尿生殖道解脲支原体(UU)、人型支原体(MH)、沙眼衣原体(CT)感染状况及支原体的耐药性,为临床合理用药提供依据。方法:对1 235例妇科门诊就诊的不孕症患者进行支原体、衣原体的筛查,并对支原体阳性标本进行药敏分析。结果:1 235例不孕症患者中支原体或衣原体阳性569例,阳性检出率为46.1%,其中UU感染460例,感染率为37.2%;UU+MH感染62例,感染率为10.9%;MH感染24例,感染率为4.2%;CT感染9例,感染率为1.6%。继发不孕组人群的UU、MH、UU+MH的感染率显著高于原发不孕组(P<0.05)。UU对强力霉素、交沙霉素、克拉霉素的敏感性较高(均在95.0%以上),MH对强力霉素的敏感性最高(91.7%),UU+MH对强力霉素、克拉霉素、交沙霉素的敏感性较高(均在91.0%以上)。结论:在妇科不孕症患者(尤其是继发性不孕症患者)中,UU、UU+MH感染的发生率较高,在治疗时针对不同的个体合理选择敏感性高、耐药性低的药物进行准确的治疗。
Objective: To understand the urogenital ureaplasma urealyticum (UU), mycoplasma hominis (MH), chlamydia trachomatis (CT) infection and mycoplasma resistance in female genitourinary tract, and to provide basis for clinical rational drug use. Methods: A total of 1 235 gynecological outpatients with infertility were screened for mycoplasma and chlamydia, and drug sensitivity analysis of mycoplasma positive specimens. Results: The positive rate of mycoplasma or chlamydia in 1 235 infertility patients was 569, the positive rate was 46.1%. Among them, 460 cases were UU infection and the infection rate was 37.2%. UU + MH infection was 62 cases and the infection rate was 10.9%. MH infection in 24 cases, the infection rate was 4.2%; CT infection in 9 cases, the infection rate was 1.6%. The infection rates of UU, MH and UU + MH in the infertile group were significantly higher than those in the primary infertility group (P <0.05). UU was more sensitive to doxycycline, josamycin and clarithromycin (all above 95.0%), MH was the highest sensitive to doxycycline (91.7%), UU + MH against doxycycline, The sensitivity of Jomyomycin and jasamycin were higher (all above 91.0%). Conclusion: The incidence of UU and UU + MH infection is higher in patients with gynecological infertility (especially in patients with secondary infertility), which is highly sensitive and reasonable to different individuals in treatment. The exact treatment of the drug.