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一、排卵首次提出前列腺素参与调节卵巢卵泡的机能这一概念系基于前列腺素合成的抑制剂(如阿斯匹林和消炎痛)能阻断大鼠的排卵。此后,在其它几种动物,如小鼠、兔、恒河猴、狨猴、猪和金鱼等,也观察到这一作用。将前列腺素(PGs)合成的抑制剂局部应用于兔或金鱼的卵泡也能阻断排卵,这提示阻断作用是直接作用于卵泡而不是经过某些间接机制(如通过抑制促性腺激素的分泌)来中介的。进而发现,在几种上述的动
First, ovulation Put forward the concept of prostaglandin involved in the regulation of ovarian follicles The concept is based on prostaglandin synthesis inhibitors (such as aspirin and indomethacin) can block rat ovulation. Since then, this effect has also been observed in several other animals, such as mice, rabbits, rhesus macaques, marmosets, pigs and goldfish. Topical application of inhibitors of prostaglandin (PGs) synthesis to ovarian follicles in either rabbit or goldfish also blocked ovulation, suggesting that the blockade acts directly on the follicles rather than through some indirect mechanisms (such as by inhibiting gonadotropin secretion ) To intermediary. And then found that in several of the above move