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0——对甲苯磺酰乳酸甲指(CH_3-(?)—SO_2-O-(?)-COOCH_3)是一步羧烷化法合成非甾体消炎药布洛芬的中间体.消炎镇痛解热药布洛芬〔α-(4′—异丁基)—丙酸〕是治疗风湿性关节炎等炎症的特效药。目前国内外一些生产布洛芬厂家采用的制备方法大都合成路线长,操作繁杂、需用金属钠、镁、腈化物、硝酸银等危险性大或剧毒或价格昂贵的原料,给工业制备带来了不利,且使药价很贵。而一步羧烷化是将0—对甲
0 - p-toluenesulfonyllactate methyl means (CH3 - (-) - SO2-O - (?) - COOCH3) is a one-step carboxyalkylation synthesis of non-steroidal anti-inflammatory drugs ibuprofen intermediates. Hot drug ibuprofen [α- (4’-isobutyl) -propionic acid〕 is the treatment of rheumatoid arthritis and other inflammatory drugs. At present, some domestic and foreign manufacturers of ibuprofen production methods used in the synthesis of long route, complicated operation, the need to use sodium metal, magnesium, nitrile, silver nitrate and other dangerous or highly toxic or expensive raw materials to the industrial preparation with Comes bad, and the price is very expensive. The one-step carboxyalkylation is 0-on