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自60年代开始,人们发现了很多有生物活性的多糖,并开始探讨其结构,在宏观和微观方面均取得了满意的结果。目前,研究得较多的是多糖的化学结构与抗肿瘤、抗辐射、抗凝血及降血脂等之间的关系,同时对多糖的作用机制也作了研究。一、降解法提高多糖活性:从中药茯苓中提取的茯苓多糖(pachyman)的基本结构为β(1→3)键的葡聚糖,小鼠抗肿瘤实验表明它不具抗肿瘤活性。经进一步分析其结构,发现 pachyman 除主链β(1
Since the 1960’s, many biologically active polysaccharides have been discovered and their structures have been explored. Satisfactory results have been achieved both macroscopically and microscopically. At present, the research is more on the chemical structure of polysaccharides and anti-tumor, anti-radiation, anticoagulant and hypolipidemic relationship between the same time, the mechanism of action of polysaccharides have also been studied. First, the degradation method to improve the activity of polysaccharides: extracted from the traditional Chinese medicine Poria in the pachyman (pachyman) the basic structure of β (1 → 3) bond dextran, anti-tumor experiments in mice showed that it does not have anti-tumor activity. After further analysis of its structure, found that pachyman except the main chain β (1