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目的：评价采用环磷酰胺、阿霉素、顺铂（ＣＡＰ方案）联合治疗晚期乳腺癌的疗效。方法：远处转移性乳腺癌３１例，其中８例为初治（包括以前用过辅助化疗４例），５例有两个部位转移，８例有三个部位转移。环磷酰胺５００ｍｇ／ｍ２静冲，第１天、第８天，阿霉素４００ｍｇ／ｍ２，第１天，顺铂３０ｍｇ／ｍ２静滴，第３～５天，２１天为一周期。结果：总有效率７４．３％（２３／３１），完全缓解率９．７％（３／３１），中位缓解期６月，中位生存期１２．６月。对软组织转移有效率６８％（１５／２２），肺转移有效率为４／７，肝、胸膜、肾上腺、骨转移有效率分别为５／６、３／３、２／３、１／１。本组患者有不同程度胃肠反应，其中Ⅲ度占５４．８％，白细胞减少（Ⅲ度）占４１．９％。未发现肾毒性。结论：ＣＡＰ方案是治疗晚期乳腺癌的较好方案
Objective: To evaluate the efficacy of combination chemotherapy with cyclophosphamide, doxorubicin, and cisplatin (CAP) in the treatment of advanced breast cancer. Methods: 31 cases of distant metastatic breast cancer, of which 8 cases were initially treated (including 4 cases of previously used adjuvant chemotherapy), 5 cases had two site metastases, and 8 cases had 3 site metastases. Cyclophosphamide 500mg/m2 static flushing, on the 1st and 8th day, doxorubicin 400mg/m2, on the 1st, cisplatin 30mg/m2 intravenous infusion, on the 3rd to 5th, 21st cycle. Results: The total effective rate was 74.3% (23/31), the complete remission rate was 9.7% (3/31), the median remission period was 6 months, and the median survival period was 12.6 months. The effective rate of soft tissue transfer was 68% (15/22), the effective rate of lung metastasis was 4/7, and the effective rates of hepatic, pleural, adrenal, and bone metastases were 5/6, 3/3, 2/3, and 1/1, respectively. This group of patients had different degrees of gastrointestinal reactions, including III degree 54.8%, leukopenia (III degree) accounted for 41.9%. No nephrotoxicity was found. Conclusion: CAP is a better treatment for advanced breast cancer