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心得安能减慢心率和降低心肌收缩力,从而减少心肌需氧量,保护缺血心肌,因而推荐用来治疗急性缺血性心脏病。但是,心得安的心肌抑制作用对心功能是有害的。本文通过对清醒狗缺血心脏的实验,评价哇巴因和心得安联合应用的作用。方法:21只狗,经麻醉手术,在左室内安置微型压力计,冠状动脉左前降支或回旋支安置Doppler超声血流换能器,其远端安置水力闭塞器;左房和主动脉安置Tygon导管。在可能正常、中度和严重缺血区的心肌内置放六对微型超声换能器。用改良的超声“通过时间”(transit-time)长度计测定局部心肌节段长度,并利用超声换能器作为
Anneng can slow down the heart rate and reduce myocardial contractility, thereby reducing myocardial oxygen demand, protecting ischemic myocardium, which is recommended for the treatment of acute ischemic heart disease. However, prophylactic myocardial inhibition is detrimental to cardiac function. In this paper, awake dog ischemic heart experiments to evaluate the combination of ouabain and propranolol role. METHODS: Twenty-one dogs underwent anesthesia. A miniature manometer was placed in the left ventricle, and the Doppler ultrasonic transducer was placed on the left anterior descending coronary artery or the circumflex artery. The hydraulic occluder was placed on the distal end of the device. Tygon was placed in the left atrium and the aorta catheter. Six pairs of miniature ultrasound transducers are built into the myocardium that may be normal, moderate, and severely ischemic. Local myocardial segment length was determined using a modified ultrasound “transit-time” length meter and using an ultrasound transducer as