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六甲氧苄嗪(hexametazidine)具有浓度依赖的负性变力作用(IC 50=81.8±16.9μmol/L).细胞外Ca~(2+)从1.8mmol/L提高到5.4mmol/L,可完全对抗六甲氧苄嗪(30.8μmol/L)的负性变力作用,六甲氧苄嗪(30.8μmol/L)可使肾上腺素诱导自律性的阈浓度从3.95±1.80提高到6.67±4.84μmol/L(P<0.05);61.6μmol/L使心肌的功能不应期从218±14延长至254±20ms(P<0.05),六甲氧苄嗪6.2μmol/L可竞争性地拮抗异丙肾上腺素的正性变力效应(PA_2=5.45);15.41μmol/L非竞争性地拮抗组胺的正性变力效应(pD_2′=4.13)。
Hexametazidine has a concentration-dependent negative inotropic effect (IC 50 = 81.8 ± 16.9 μmol / L), while extracellular Ca 2+ increased from 1.8 mmol / L to 5.4 mmol / L, The negative effect of hexamethoxazole (30.8μmol / L) and hexamethonium (30.8μmol / L) increased the threshold concentration of adrenaline-induced self-regulation from 3.95 ± 1.80 to 6.67 ± 4.84μmol / L (P <0.05). 61.6μmol / L prolonged cardiac refractory period from 218 ± 14 to 254 ± 20ms (P <0.05), and 6μmol / L of Ketoconazole could competitively antagonize isoproterenol The positive variable effect (PA_2 = 5.45) and non-competitive positive antagonistic effect of histamine at 15.41μmol / L (pD_2 ’= 4.13).