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目的对东北红豆杉(Taxus cuspidtaSibe.et Zucc.)的化学成分进行研究。方法采用硅胶柱色谱等方法进行分离纯化,根据理化性质和NMR波谱数据进行结构鉴定。结果分离得到8个化合物,分别鉴定为大黄素甲醚(physcion,1)、油酸甲酯(methyl oleate,2)、紫杉宁(taxinine,3)、5α-羟基-9α,10β,13α-三乙酰氧紫杉烷-4(20),11-二烯(5α-hydroxy-9α,10β,13α-triacetoxytaxa-4(20),11-diene,4)、云南紫杉宁C(taxuyunnanine C,5)、2-去乙酰氧-5α-羟基紫杉宁J(2-deacetoxydecin-namoyl taxinine J,6)、2-去乙酰氧紫杉宁J(2-deacetoxytaxinine J,7)、11-羟基-12-甲氧基松香烷-8,11,13-三烯-3,7-二酮(11-hydroxy-12-methoxyabieta-8,11,13-triene-3,7-dione,8)。结论化合物1、2为首次从红豆杉属植物中分离得到,化合物4、8为首次从该种植物中分离得到。
Objective To study the chemical constituents of Taxus cuspidta Sibe.et Zucc. Methods The compounds were isolated and purified by silica gel column chromatography. The structures were identified by physicochemical properties and NMR spectral data. Results Eight compounds were isolated and identified as physcion (1), methyl oleate (2), taxinine (3), 5α-hydroxy-9α, 10β, 13α- Triacetyloxytaxane-4(20),11-diene (5α-hydroxy-9α,10β,13α-triacetoxytaxa-4(20),11-diene,4), taxuyunnanine C, 5) 2-deacetoxydecin-namoyl taxinine J (6), 2-deacetoxytaxinine J (7), 11-hydroxy- 12-methoxyrosin-8,11,13-triene-3,7-dione (11-hydroxy-12-methoxyabieta-8,11,13-triene-3,7-dione,8). Conclusion Compounds 1 and 2 were isolated from Taxus for the first time. Compounds 4 and 8 were isolated from this plant for the first time.