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中药的临床应用建立在辨证的基础上,因此其药效评价也应该建立在中医证候分类的基础之上。通过药效学实验阐明中药治疗疾病的药效作用特点及其机制,揭示中药作用机制的科学内涵,是中药现代化和国际化的必然要求,也是探索药物作用靶点,指导临床合理用药的关键所在。如何利用成熟疾病动物模型,并明确其证候特征,是中药药效评价载体研究的关键问题。随着生物医学的发展,通过研究疾病动物模型的生物学指标有可能分析得出该疾病动物模型的证候特性。利用以方测证方法,建立针对该疾病常见证候类型且临床验证有效的中药干预疾病动物模型,并将治疗有效的动物作为体现相应证候特征的动物模型,通过探寻其现代生物学基础,确立相应的中医证候特征相关指标,从而明确疾病动物模型的证候特征,是建立适合辨证论治中药药效评价动物模型的重要途径。建立基于中医证候分类的中药药效评价研究方法,将有助于从中医理论出发提高我国中药研发水平。
The clinical application of traditional Chinese medicine is based on syndrome differentiation, so its efficacy evaluation should also be based on TCM syndrome classification. Through the pharmacodynamic experiments to clarify the characteristics and mechanism of traditional Chinese medicine treatment of disease efficacy and reveal the scientific connotation of traditional Chinese medicine mechanism of action is the inevitable requirement of the modernization and internationalization of Chinese medicine is also the key to explore the role of drug targets to guide clinical rational use of drugs . How to use the animal model of mature disease and clarify the characteristics of syndromes are the key issues in the study of Chinese medicine efficacy evaluation carrier. With the development of biomedicine, it is possible to analyze the syndrome characteristics of the animal model of the disease by studying the biological indicators of the animal model of disease. By using the method of square test to establish the animal model of traditional Chinese medicine intervention disease which is suitable for the common syndrome type of the disease and has been clinically validated, and treating the animal with effective treatment as the animal model embodying the corresponding syndrome characteristics, by exploring its modern biological foundation, Establishing the corresponding index of traditional Chinese medicine syndrome characteristics so as to clarify the syndrome characteristics of the animal model of disease is an important way to establish an animal model suitable for evaluating the TCM efficacy of syndrome differentiation. To establish a research method of TCM efficacy evaluation based on the classification of TCM syndromes will help to improve the research and development level of TCM in our country.