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目的观察头孢西丁、头孢克肟序贯疗法治疗儿童社区获得性肺炎的临床效果。方法选择2012年1—12月治疗的社区获得性肺炎患儿60例,随机分为治疗组和对照组各30例,治疗组给予头孢西丁100-150 mg.kg-1.d-1+100 ml生理盐水静脉注射,间隔6-8 h分2次给药,治疗2-3 d后,改为头孢克肟颗粒3-6 mg.kg-.1d-1口服,分2次给药,口服至第5-7 d;对照组仅静脉注射头孢西丁7-10 d,用法用量同治疗组。比较两组疗效、门诊天数、总治疗天数、治疗费用。计量资料采用t检验,计数资料采用χ2检验,P<0.05为差异有统计学意义。结果两组总有效率均为100.0%,无差异。门诊天数治疗组[(2.80±0.43)d]与对照组[(8.40±1.04)d]比较差异有统计学意义(t=27.255,P<0.05)。治疗费用治疗组[(196.80±23.99)元]与对照组[(489.00±60.39)元]比较差异有统计学意义(t=24.630,P<0.05)。结论头孢西丁、头孢克肟序贯疗法治疗儿童社区获得性肺炎经济有效,值得推广。
Objective To observe the clinical efficacy of cefoxitin and cefixime sequential therapy in children with community-acquired pneumonia. Methods Sixty children with community-acquired pneumonia who were treated in January-December 2012 were randomly divided into treatment group (30 cases) and control group (30 cases). The treatment group was given cefoxitin 100-150 mg.kg-1.d-1 + 100 ml saline intravenously, 6-8 h intervals 2 times, after 2-3 days of treatment, cefixime particles to 3-6 mg.kg-.1d-1 orally, divided into 2 doses, Oral 5-7 d; control group only cefoxitin intravenous 7-10 d, the amount of use the same treatment group. The curative effect, outpatient days, total treatment days and treatment costs were compared between the two groups. Measurement data using t test, count data using χ2 test, P <0.05 for the difference was statistically significant. Results The total effective rate was 100.0% in both groups, no difference. The number of outpatient days in the treatment group [(2.80 ± 0.43) d] was significantly different from that in the control group [(8.40 ± 1.04) d] (t = 27.255, P <0.05). The treatment cost of treatment group [(196.80 ± 23.99) yuan vs control group (489.00 ± 60.39) yuan] was significantly different (t = 24.630, P <0.05). Conclusion Cefoxitin and cefixime sequential treatment of children with community-acquired pneumonia is cost-effective, it is worth promoting.