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The effect of hot isostatic pressing treatment on the fatigue crack growth behavior of Ti-6Al-4V alloy fabricated by electron beam melting was investigated.The results indicate that the fatigue crack growth rate of the HIPed samples is higher than that of the as-fabricated one under certain stress intensity factor (△K ＜ 18 MPa m1/2).With further increase in △K,the fatigue crack growth rates of the studied two samples become similar.The variation of α lamella thickness and the pore defects distribution have an effect on the fatigue crack growth rates in the studied samples,and the latter plays the dominant role.