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少数白血病患者外周血的白细胞异常增多,给治疗带来了特殊问题。由于白血病幼稚细胞对肺、脑及其它器官循环的影响,在血、骨髓和组织中,大量白血病细胞被细胞毒性药物杀灭所造成的代谢问题,白细胞异常增高使血液粘度超过正常,多数患者血液粘度增加虽未超过正常,但微循环的粘度却增高。此外,幼稚细胞有耗氧高及组织浸润等特点,与血流改变相互影响,损伤血管,导致器官功能异常。细胞变形能力和比积决定粘度在血流率高的情况下,血细胞引起血液粘度增加的两因素是细胞变形能力和比积。当白细胞比积增大时,其粘度成对数级增高。白细胞
A small number of leukemia in peripheral blood leukocyte abnormalities, to the treatment of a special problem. Because leukemia naive cells affect the circulation of the lungs, brain and other organs, the metabolic problems caused by the killing of a large number of leukemic cells in the blood, bone marrow and tissues by cytotoxic drugs, the abnormal increase in white blood cells make the blood viscosity more than normal, and most patients’ blood Although the viscosity increase does not exceed the normal, but the microcirculation viscosity is increased. In addition, naive cells with high oxygen consumption and tissue infiltration and other characteristics, and blood flow changes affect each other, damage blood vessels, leading to organ dysfunction. Cell deformability and specific products to determine the viscosity in the case of high blood flow, blood cells caused by increased blood viscosity of the two factors is the cell deformability and specific product. As the leukocyte product increases, its viscosity increases logarithmically. leukocyte