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本研究试图通过对恶性疟患者外周血液中配子体的检出时间,持续时间以及密度的观察、以评价药物对恶性疟原虫配子体的作用。作者在泰国西部恶性疟流行区,用厚血片检查法选择了观察对象,分为两组,A组(77例)患者血液中仅含无性体原虫,都用法西达常规剂量治疗。B组(14例)患者血液中仅含配子体期,未用抗疟药治疗。两组均从试验日开始每周作一次血片检查,直到原虫血症转阴为止。从发现无性体的第1周到发现配子体的第1周,为配子体前期的所需时间。从第1次由外周血检出配子体到疟原虫转阴为配子
This study attempted to evaluate the effect of drugs on P. falciparum gametocytes by monitoring the timing, duration and density of gametocytes in peripheral blood of patients with falciparum malaria. In the endemic area of falciparum malaria in western Thailand, the authors selected the observation objects by thick film examination and divided them into two groups. The patients in group A (77 patients) contained only asexual blood in the blood and were treated with the conventional dose of faxid. Group B (14 patients) contained only gametophy in the blood and were not treated with antimalarial drugs. Both groups began weekly blood tests from the test day until parasitemia became negative. The first week from the discovery of asexuality to the first week of discovery of gametophyte is the time required for pre-gametophyte growth. From the first detection of peripheral blood from gametocytes to malaria parasites as gametes