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目的实验室合成蛙皮素活性肽、阿霉素、固体脂质纳米粒构成的高效复合物(Bn-DOX/SLNs),通过动物实验评估Bn-DOX/SLNs抗人乳腺癌细胞的作用。方法实验室合成Bn-DOX/SLNs,测定并比较BnDOX/SLNs与对照组粒子的理化特性包括粒子大小、表面点位量测、药物负载量、诱导药物能力、体外药物的释放效率,并评测在动物模型中抗人乳腺癌细胞的作用。结果 Bn-DOX/SLNs能明显降低人乳腺癌细胞MCF-7/MDR对阿霉素的耐药性,并且能在小鼠体内明显提高阿霉素抗人乳腺癌细胞的活性。结论 Bn-DOX/SLNs能明显降低阿霉素的耐药性,可用于临床乳腺癌患者的化疗。
Objective To evaluate the effect of Bn-DOX / SLNs against human breast cancer cells by using Bn-DOX / SLNs, an effective peptide of doxorubicin, doxorubicin and solid lipid nanoparticles. Methods The Bn-DOX / SLNs were synthesized in the laboratory. The physical and chemical properties of BnDOX / SLNs and control group were measured and compared. Particle size, surface point measurement, drug loading, drug inducing ability and drug release efficiency were evaluated. Anti-human breast cancer cells in animal models. Results Bn-DOX / SLNs could significantly reduce the drug resistance to doxorubicin in human breast cancer cell line MCF-7 / MDR and significantly enhance the activity of doxorubicin against human breast cancer cells in mice. Conclusion Bn-DOX / SLNs can significantly reduce the drug resistance of doxorubicin, which can be used in the chemotherapy of clinical breast cancer patients.