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非甾体类消炎药(nonsteroidal antiinflammatory drugs,NSAIDs)在临床得到越来越广泛的使用,但可出现明显的胃肠道不良反应,使消化性溃疡的发病率、并发症及死亡率明显升高。因此防治NSAIDs引起的胃十二指肠损伤已成为当今临床上的一个重要课题。目前研究主要集中在NSAIDs溃疡发病机制、幽门螺杆菌感染与NSAIDs胃肠损伤的关系及特异性COX-2抑制剂研制等方面。对于NSAID溃疡的预防及治疗,前列腺素E、H2受体拮抗剂、质子泵抑制剂、胃粘膜保护剂等均有使用,但治疗方案还没有共识。如何选用上述药物及其疗效如何仍存在争议。以下的系统评价对NSAIDs胃肠损伤的药物防治进行了评估。可作为临床治疗时参考。
Nonsteroidal antiinflammatory drugs (NSAIDs) have been used more and more widely in clinical practice, but there are obvious gastrointestinal adverse reactions and the incidence, complication and mortality of peptic ulcer are significantly increased . Therefore, prevention and treatment of gastroduodenal injury caused by NSAIDs has become an important issue in clinical practice. The current research focuses on the pathogenesis of NSAIDs ulcer, Helicobacter pylori infection and NSAIDs gastrointestinal injury and the development of specific COX-2 inhibitors. For the prevention and treatment of NSAID ulcer, prostaglandin E, H2 receptor antagonists, proton pump inhibitors, gastric mucosal protective agent Dengjun use, but there is no consensus treatment. How to choose the above drugs and how effective is still controversial. The following systematic reviews evaluated the drug control of gastrointestinal injury in NSAIDs. Can be used as a reference for clinical treatment.